Trends in Organic Chemistry
Carbohydrates
Monday 21 November 2005
Beijersalen
The Royal Swedish Academy of Sciences
In living systems, carbohydrates serve not only as energy storage and structural compounds, but are also involved in important specific events on the cellular level such as antigen-antibody interactions, bacterial adhesion, embryogenesis, neuronal development, cell proliferation, inflammation, and glycoprotein transport. The increased appreciation of the biological role of carbohydrates has resulted in a revived interest in carbohydrate chemistry. During the last decades, reliable glycosylation methods and strategies to construct complex oligosaccharides have become available. Furthermore, the first steps have been taken towards routine assembly of oligosaccharides on solid supports and to construct oligosaccharide libraries. Enzymatic approaches allow the synthesis of particular oligosaccharides avoiding tedious protecting group manipulations. Glycopeptides can be conveniently prepared on solid supports from preassembled commercially available building blocks. The well-defined saccharides that have become available by the application of these synthetic methodologies have played pivotal roles in the elucidation of many biological processes. Synthetic or semi-synthetic carbohydrate derivatives have also in some instances advanced to stage of approved commercial drugs or vaccines.
The symposium forms part of the series ”Trends in Organic Chemistry” sponsored by the Swedish Chemical Society Division of Organic Chemistry.
Preliminary program:
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09.30-09.50 |
Coffee |
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09.50-10.00 |
Welcome |
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10.00-11.00 |
Carbohydrate-gold-nanoparticles
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11.00-12.00 |
Ring-closing olefin metathesis - Method development and synthetic
applications
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12.00-13.00 |
Lunch |
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13.00-14.00 |
Stereoselective glycosylations using chiral auxiliaries
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14.00-15.00 |
Helicobacter pylori - A model for microbial adhesion mediated byfucosylated
blood group antigens
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15.00-15.30 |
Coffee |
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15.30-16.30 |
Automated
carbohydrate synthesis and carbohydrate arrays to create vaccines against
anthrax and malaria
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16.30-17.30 |
Synthetic
carbohydrate vaccines
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Participation in the scientific programme is free of charge. Coffee will be served in the morning and afternoon for SEK 20 respectively. A sitting lunch at "Klubbvillan" including mineral water or low-alcohol beer and coffee for SEK 120 will be provided. Please register participation in the programme and lunch by e-mail to johanna@chemsoc.se, no later than November 7, 2005.
Payment of the lunch should be made via postal giro 78 25 73-0 prior 14 November 2005. Indicate “Carbohydrates” and your name on the money transfer. The coffee will be paid at the symposium.
Location: Beijersalen,The Royal Swedish Academy of Sciences, Lilla Frescativägen 4A, Stockholm (link to map)
Symposium hosts: Prof Peter Konradsson, IFM/Chemistry, Linköping University, prof Stefan Oscarsson, Organic Chemistry, Stockholm University and prof Thomas Norberg, Organic Chemistry, SLU.
Sponsors: AstraZeneca R&D.
Welcome!
The Division of Organic Chemistry